Because of the potential for pleiotropic effects, statin therapy is currently being considered for medical conditions beyond cardiovascular disease. The word has been borrowed to the world of pharmacology where it is used to refer to actions of drugs that are not their main or intended action.
Pleiotropic effects of statins. eNOS ϭ endothelial nitric
These pleiotropic actions include direct effects on vascular tissue, kidney, bone, and glucose metabolism.
Pleiotropic effect of statin. “pleiotropic effects of statins involve improving endothelial function, decreasing vascular inflammation and oxidative stress, and inhibiting the thrombogenic response. Or “pleiotropic” effects of statin include the upregulation and activation of endothelial nitric acid synthase (enos) that can increase nitric oxide (no) production. Overall, the literature supports beneficial pleiotropic effects of statin use in contrastinduced nephropathy, head injury, alzheimer’s and parkinson’s disease, nuclear cataract, prostate cancer, infection management, and spinal cord injury.
Seleprotein synthesis and side effects of statin. Circulating telomerase activity is an important determinant of telomere stability and length, but whether different telomerase activity levels may affect ltl. Pleiotropic effects of statin therapy:
The word pleiotropic originally referred to a gene that influenced or affected more than one trait in an organism, several phenotypic expressions. Objectives statins appear to have pleiotropic effects. Moreover, some works shows statins’ beneficial extrahepatic effects on the immune system, cns, and bone.
Reductase, but differ between each other in the extent of this inhibition pleiotropic effects of statins numerous and varied, it may add to. Statins are believed to have “pleiotropic effects”, which is a term referred as the useful impacts of statins which are not dependent on levels of cholesterol. A new pleiotropic effect of statins in elderly:
Recent studies have shown that statins might have important roles in diseases that are not mediated by cholesterol. The canonical function of the statins is the inhibition of cholesterol biosynthesis. Statins have pleiotropic effects, ie the ability to reduce heart disease risk and cv death via an unknown mechanism, certainly beyond.
Modulation of telomerase activity virginia boccardi, michelangela barbieri, maria rosaria rizzo, raffaele marfella, antonietta esposito, luigi marano, and giuseppe paolisso1 department of internal medicine, surgical, neurological, metabolic disease and geriatric medicine, Lee jk, won js, singh ak, singh i. As a validation, we assessed whether a drug that unexpectedly likely increases ihd also operates via testosterone.
8,9 according to these pleiotropic impacts, positive results utilizing statin treatment have been acknowledged in cardiovascular disease (cvd) and in addition other ailment states including disease, sepsis,. Due to the pleiotropic effects, the focus on statins has shifted from being considered harmful to something useful. A potential pleiotropic target for statins in stroke is the effect of statins on enos, given that mice without enos demonstrate larger infarcts.
Desireable effect of a drug and interfere the treatment Recently, brachial artery vasoreactivity trial (bart) reported that statins could improve endothelial dysfunction. They are usually prescribed as a lipid lowering medication.
Statins display pleiotropic effects on neuronal and glial cells, diminishing ggpp and. 155 the effects of statins are likely mediated by rho/rock because rock inhibitors upregulate enos and improve cerebral blood flow in. 1,2 they include increases in endothelial nitric oxide formation;
Statins decrease de novo cholesterol biosynthesis and thereby reduce plasma cholesterol levels. The net effect of statins depends on their hydrophobicity, pharmacokinetics and metabolism. The pleiotropic effects attributed to statins are many.
Statins are a class of molecules that inhibit hmg coa reductase. Molecular mechanisms and clinical results. The noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability) as being the major modulators of clinical benefit.
This narrative review of the literature aims to provide the reader with. Moreover, since there is no direct effect of statins on macrophage function, we believe that the known beneficial pleiotropic effect of statin treatment on cardiovascular mortality is based on the impact on mscs to differentiate into macrophages and thereby effectively increase plaque stability. We examined whether specifically statins, of the major lipid modifiers, operate on ischemic heart disease (ihd) via testosterone.
Although the underlying mechanism is unknown, it could constitute a new and modifiable pleiotropic effect of statin. Wang cy, liu py, liao jk, et al. Conclusion statins have same mode of action via inhibition of hmg coa.
